A team of researchers from the School of Biological Sciences found some answers to the mystery of gene regulation by turning to the trusty roundworm C. elegans, a frequently studied model organism that has contributed to many important discoveries. In their new study published in GENETICS, the researchers used a powerful new approach to compare gene activity across several types of wildly diverse worm strains from all over the world to uncover their regulatory structure.

In this first of its kind study, the researchers crossed each strain of worm with their standard N2 lab strain to make a hybrid offspring. They then used a modern and powerful technique called allele-specific RNA sequencing to determine how the genes were being used in these new strains, and which parent DNA is driving the gene’s activity.